Conformational manipulation of scale-up prepared single-chain polymeric nanogels for multiscale regulation of cells

Xiaoyu Chen, Rui Li, Siu Hong Dexter Wong, Kongchang Wei, Miao Cui, Huaijun Chen, Yuanzhang Jiang, Boguang Yang, Pengchao Zhao, Jianbin Xu, Heng Chen, Chao Yin, Sien Lin, Wayne Yuk-Wai Lee, Yihan Jing, Zhen Li, Zhengmeng Yang, Jiang Xia, Guosong Chen, Gang Li and Liming Bian ()
Additional contact information
Xiaoyu Chen: The Chinese University of Hong Kong
Rui Li: The Chinese University of Hong Kong
Siu Hong Dexter Wong: The Chinese University of Hong Kong
Kongchang Wei: Laboratory for Biomimetic Membranes and Textiles
Miao Cui: Beijing Genomic Institute-Shenzhen
Huaijun Chen: Fudan University
Yuanzhang Jiang: The Hong Kong Polytechnic University
Boguang Yang: The Chinese University of Hong Kong
Pengchao Zhao: The Chinese University of Hong Kong
Jianbin Xu: Zhejiang University
Heng Chen: Shenzhen University
Chao Yin: The Chinese University of Hong Kong
Sien Lin: The Chinese University of Hong Kong, Prince of Wales Hospital
Wayne Yuk-Wai Lee: The Chinese University of Hong Kong, Prince of Wales Hospital
Yihan Jing: The Chinese University of Hong Kong
Zhen Li: Fudan University
Zhengmeng Yang: The Chinese University of Hong Kong, Prince of Wales Hospital
Jiang Xia: The Chinese University of Hong Kong
Guosong Chen: Fudan University
Gang Li: The Chinese University of Hong Kong, Prince of Wales Hospital
Liming Bian: The Chinese University of Hong Kong

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Folded single chain polymeric nano-objects are the molecular level soft material with ultra-small size. Here, we report an easy and scalable method for preparing single-chain nanogels (SCNGs) with improved efficiency. We further investigate the impact of the dynamic molecular conformational change of SCNGs on cellular interactions from molecular to bulk scale. First, the supramolecular unfoldable SCNGs efficiently deliver siRNAs into stem cells as a molecular drug carrier in a conformation-dependent manner. Furthermore, the conformation changes of SCNGs enable dynamic and precise manipulation of ligand tether structure on 2D biomaterial interfaces to regulate the ligand–receptor ligation and mechanosensing of cells. Lastly, the dynamic SCNGs as the building blocks provide effective energy dissipation to bulk biomaterials such as hydrogels, thereby protecting the encapsulated stem cells from deleterious mechanical shocks in 3D matrix. Such a bottom-up molecular tailoring strategy will inspire further applications of single-chain nano-objects in the biomedical area.

Date: 2019
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DOI: 10.1038/s41467-019-10640-z

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