HIV-1 DNA sequence diversity and evolution during acute subtype C infection

Guinevere Q. Lee, Kavidha Reddy, Kevin B. Einkauf, Kamini Gounder, Joshua M. Chevalier, Krista L. Dong, Bruce D. Walker, Xu G. Yu, Thumbi Ndung’u and Mathias Lichterfeld ()
Additional contact information
Guinevere Q. Lee: Ragon Institute of MGH, MIT and Harvard
Kavidha Reddy: University of KwaZulu-Natal
Kevin B. Einkauf: Ragon Institute of MGH, MIT and Harvard
Kamini Gounder: University of KwaZulu-Natal
Joshua M. Chevalier: Ragon Institute of MGH, MIT and Harvard
Krista L. Dong: Ragon Institute of MGH, MIT and Harvard
Bruce D. Walker: Ragon Institute of MGH, MIT and Harvard
Xu G. Yu: Ragon Institute of MGH, MIT and Harvard
Thumbi Ndung’u: Ragon Institute of MGH, MIT and Harvard
Mathias Lichterfeld: Ragon Institute of MGH, MIT and Harvard

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Little is known about the genotypic make-up of HIV-1 DNA genomes during the earliest stages of HIV-1 infection. Here, we use near-full-length, single genome next-generation sequencing to longitudinally genotype and quantify subtype C HIV-1 DNA in four women identified during acute HIV-1 infection in Durban, South Africa, through twice-weekly screening of high-risk participants. In contrast to chronically HIV-1-infected patients, we found that at the earliest phases of infection in these four participants, the majority of viral DNA genomes are intact, lack APOBEC-3G/F-associated hypermutations, have limited genome truncations, and over one year show little indication of cytotoxic T cell-driven immune selections. Viral sequence divergence during acute infection is predominantly fueled by single-base substitutions and is limited by treatment initiation during the earliest stages of disease. Our observations provide rare longitudinal insights of HIV-1 DNA sequence profiles during the first year of infection to inform future HIV cure research.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-019-10659-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10659-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-10659-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().