Graphene oxide enabled long-term enzymatic transesterification in an anhydrous gas flux

Weina Xu, Zhongwang Fu, Gong Chen, Zheyu Wang, Yupei Jian, Yifei Zhang, Guoqiang Jiang, Diannan Lu, Jianzhong Wu and Zheng Liu ()
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Weina Xu: Tsinghua University
Zhongwang Fu: Tsinghua University
Gong Chen: Tsinghua University
Zheyu Wang: Tsinghua University
Yupei Jian: Tsinghua University
Yifei Zhang: Columbia University
Guoqiang Jiang: Tsinghua University
Diannan Lu: Tsinghua University
Jianzhong Wu: University of California
Zheng Liu: Tsinghua University

Nature Communications, 2019, vol. 10, issue 1, 1-8

Abstract: Abstract Gas-phase enzymatic catalysis has been long pursued but not yet utilized in industrial processes due to many limitations. Herein, we report a hydroxyl-rich graphene oxide (GO) aerogel that can preserve the enzymatic activity and stability in an anhydrous gas flow by providing a water-like microenvironment. Lipase immobilized in the GO aerogel exhibits a 5 to 10-fold increase in apparent activity than the lyophilized lipase powder in transesterification of geraniol and vinyl acetate in the gas phase and maintains the initial activity for more than 500 h. The solid-state circular dichroism measurement confirms that the lipase keeps its native conformation in the aerogel, and the thermogravimetric analysis shows that water molecules essential for the lipase activity can be replaced by the hydroxyl groups at the GO surface. The versatility of this method is demonstrated for two other lipases with different structures, promising unprecedented applications of enzyme-GO aerogels to gas-phase enzymatic catalysis.

Date: 2019
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DOI: 10.1038/s41467-019-10686-z

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