The role of PS 18:0/18:1 in membrane function

Tore Skotland () and Kirsten Sandvig
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Tore Skotland: Oslo University Hospital
Kirsten Sandvig: Oslo University Hospital

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Various studies have demonstrated that the two leaflets of cellular membranes interact, potentially through so-called interdigitation between the fatty acyl groups. While the molecular mechanism underlying interleaflet coupling remains to be fully understood, recent results suggest interactions between the very-long-chain sphingolipids in the outer leaflet, and phosphatidylserine PS18:0/18:1 in the inner leaflet, and an important role for cholesterol for these interactions. Here we review the evidence that cross-linking of sphingolipids may result in clustering of phosphatidylserine and transfer of signals to the cytosol. Although much remains to be uncovered, the molecular properties and abundance of PS 18:0/18:1 suggest a unique role for this lipid.

Date: 2019
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DOI: 10.1038/s41467-019-10711-1

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