Actomyosin-driven force patterning controls endocytosis at the immune synapse

Anita Kumari, Judith Pineau, Pablo J. Sáez, Mathieu Maurin, Danielle Lankar, Mabel San Roman, Katharina Hennig, Vanessa F. Boura, Raphael Voituriez, Mikael C. I. Karlsson, Martial Balland, Ana-Maria Lennon Dumenil () and Paolo Pierobon ()
Additional contact information
Anita Kumari: PSL Research University, INSERM U932, 26 rue d’Ulm
Judith Pineau: PSL Research University, INSERM U932, 26 rue d’Ulm
Pablo J. Sáez: PSL Research University, INSERM U932, 26 rue d’Ulm
Mathieu Maurin: PSL Research University, INSERM U932, 26 rue d’Ulm
Danielle Lankar: PSL Research University, INSERM U932, 26 rue d’Ulm
Mabel San Roman: PSL Research University, INSERM U932, 26 rue d’Ulm
Katharina Hennig: Laboratoire Interdisciplinaire de Physique, Université Joseph Fourier (Grenoble 1)
Vanessa F. Boura: Tumor and Cell Biology, Karolinska Institutet
Raphael Voituriez: UMR 7600 CNRS /UPMC and Laboratoire Jean Perrin, UMR 8237 CNRS /UPMC, 4 Place Jussieu
Mikael C. I. Karlsson: Tumor and Cell Biology, Karolinska Institutet
Martial Balland: Laboratoire Interdisciplinaire de Physique, Université Joseph Fourier (Grenoble 1)
Ana-Maria Lennon Dumenil: PSL Research University, INSERM U932, 26 rue d’Ulm
Paolo Pierobon: PSL Research University, INSERM U932, 26 rue d’Ulm

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract An important channel of cell-to-cell communication is direct contact. The immune synapse is a paradigmatic example of such type of interaction: it forms upon engagement of antigen receptors in lymphocytes by antigen-presenting cells and allows the local exchange of molecules and information. Although mechanics has been shown to play an important role in this process, how forces organize and impact on synapse function is unknown. We find that mechanical forces are spatio-temporally patterned at the immune synapse: global pulsatile myosin II-driven tangential forces are observed at the synapse periphery while localised forces generated by invadosome-like F-actin protrusions are detected at its centre. Noticeably, we observe that these force-producing actin protrusions constitute the main site of antigen extraction and endocytosis and require myosin II contractility to form. The interplay between global and local forces dictated by the organization of the actomyosin cytoskeleton therefore controls endocytosis at the immune synapse.

Date: 2019
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DOI: 10.1038/s41467-019-10751-7

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