Bioinspired extracellular vesicles embedded with black phosphorus for molecular recognition-guided biomineralization

Yingqian Wang, Xiaoxia Hu, Lingling Zhang, Chunli Zhu, Jie Wang (), Yingxue Li, Yulan Wang, Can Wang, Yufeng Zhang () and Quan Yuan ()
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Yingqian Wang: Wuhan University
Xiaoxia Hu: Wuhan University
Lingling Zhang: Wuhan University
Chunli Zhu: Wuhan University
Jie Wang: Wuhan University
Yingxue Li: Wuhan University
Yulan Wang: Wuhan University
Can Wang: Wuhan University
Yufeng Zhang: Wuhan University
Quan Yuan: Wuhan University

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Extracellular vesicles (EVs) are involved in the regulation of cell physiological activity and the reconstruction of extracellular environment. Matrix vesicles (MVs) are a type of EVs released by bone-related functional cells, and they participate in the regulation of cell mineralization. Here, we report bioinspired MVs embedded with black phosphorus (BP) and functionalized with cell-specific aptamer (denoted as Apt-bioinspired MVs) for stimulating biomineralization. The aptamer can direct bioinspired MVs to targeted cells, and the increasing concentration of inorganic phosphate originating from BP can facilitate cell biomineralization. The photothermal effect of the Apt-bioinspired MVs can also promote the biomineralization process by stimulating the upregulated expression of heat shock proteins and alkaline phosphatase. In addition, the Apt-bioinspired MVs display outstanding bone regeneration performance. Our strategy provides a method for designing bionic tools to study the mechanisms of biological processes and advance the development of medical engineering.

Date: 2019
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DOI: 10.1038/s41467-019-10761-5

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