Immature excitatory neurons develop during adolescence in the human amygdala

Shawn F. Sorrells, Mercedes F. Paredes, Dmitry Velmeshev, Vicente Herranz-Pérez, Kadellyn Sandoval, Simone Mayer, Edward F. Chang, Ricardo Insausti, Arnold R. Kriegstein, John L. Rubenstein, Jose Manuel Garcia-Verdugo, Eric J. Huang and Arturo Alvarez-Buylla ()
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Shawn F. Sorrells: University of California, San Francisco
Mercedes F. Paredes: University of California, San Francisco
Dmitry Velmeshev: University of California, San Francisco
Vicente Herranz-Pérez: CIBERNED
Kadellyn Sandoval: University of California, San Francisco
Simone Mayer: University of California, San Francisco
Edward F. Chang: University of California, San Francisco
Ricardo Insausti: University of Castilla-La Mancha
Arnold R. Kriegstein: University of California, San Francisco
John L. Rubenstein: University of California, San Francisco
Jose Manuel Garcia-Verdugo: CIBERNED
Eric J. Huang: University of California, San Francisco
Arturo Alvarez-Buylla: University of California, San Francisco

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract The human amygdala grows during childhood, and its abnormal development is linked to mood disorders. The primate amygdala contains a large population of immature neurons in the paralaminar nuclei (PL), suggesting protracted development and possibly neurogenesis. Here we studied human PL development from embryonic stages to adulthood. The PL develops next to the caudal ganglionic eminence, which generates inhibitory interneurons, yet most PL neurons express excitatory markers. In children, most PL cells are immature (DCX+PSA-NCAM+), and during adolescence many transition into mature (TBR1+VGLUT2+) neurons. Immature PL neurons persist into old age, yet local progenitor proliferation sharply decreases in infants. Using single nuclei RNA sequencing, we identify the transcriptional profile of immature excitatory neurons in the human amygdala between 4–15 years. We conclude that the human PL contains excitatory neurons that remain immature for decades, a possible substrate for persistent plasticity at the interface of the hippocampus and amygdala.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10765-1

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DOI: 10.1038/s41467-019-10765-1

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