Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

Dongwon Kim (), Ruosi Chen, Mary Sheu, Noori Kim, Sooah Kim, Nasif Islam, Eric M. Wier, Gaofeng Wang, Ang Li, Angela Park, Wooyang Son, Benjamin Evans, Victoria Yu, Vicky P. Prizmic, Eugene Oh, Zixiao Wang, Jianshi Yu, Weiliang Huang, Nathan K. Archer, Zhiqi Hu, Nashay Clemetson, Amanda M. Nelson, Anna Chien, Ginette A. Okoye, Lloyd S. Miller, Gabriel Ghiaur, Sewon Kang, Jace W. Jones, Maureen A. Kane and Luis A. Garza ()
Additional contact information
Dongwon Kim: Johns Hopkins University School of Medicine
Ruosi Chen: Johns Hopkins University School of Medicine
Mary Sheu: Johns Hopkins University School of Medicine
Noori Kim: Johns Hopkins University School of Medicine
Sooah Kim: Johns Hopkins University School of Medicine
Nasif Islam: Johns Hopkins University School of Medicine
Eric M. Wier: Johns Hopkins University School of Medicine
Gaofeng Wang: Johns Hopkins University School of Medicine
Ang Li: Johns Hopkins University School of Medicine
Angela Park: Johns Hopkins University School of Medicine
Wooyang Son: Johns Hopkins University School of Medicine
Benjamin Evans: Johns Hopkins University School of Medicine
Victoria Yu: Johns Hopkins University School of Medicine
Vicky P. Prizmic: Johns Hopkins University School of Medicine
Eugene Oh: Johns Hopkins University School of Medicine
Zixiao Wang: Johns Hopkins University School of Medicine
Jianshi Yu: University of Maryland
Weiliang Huang: University of Maryland
Nathan K. Archer: Johns Hopkins University School of Medicine
Zhiqi Hu: Nanfang Hospital of Southern Medical University
Nashay Clemetson: Johns Hopkins University School of Medicine
Amanda M. Nelson: The Pennsylvania State University
Anna Chien: Johns Hopkins University School of Medicine
Ginette A. Okoye: Johns Hopkins University School of Medicine
Lloyd S. Miller: Johns Hopkins University School of Medicine
Gabriel Ghiaur: Johns Hopkins University School of Medicine
Sewon Kang: Johns Hopkins University School of Medicine
Jace W. Jones: University of Maryland
Maureen A. Kane: University of Maryland
Luis A. Garza: Johns Hopkins University School of Medicine

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is uncertain. Here we show that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predicts new hair follicle formation after wounding in mice. Additionally, in humans, rejuvenation lasers induce gene expression signatures for dsRNA and RA, with measurable increases in intrinsic RA synthesis. These results demonstrate a potent stimulus for RA synthesis by non-coding dsRNA, relevant to their broad functions in development and immunity.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-019-10811-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10811-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-10811-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().