Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

Wouter A. A. Steenhuijsen Piters, Simon P. Jochems, Elena Mitsi, Jamie Rylance, Sherin Pojar, Elissavet Nikolaou, Esther L. German, Mark Holloway, Beatriz F. Carniel, Mei Ling J. N. Chu, Kayleigh Arp, Elisabeth A. M. Sanders, Daniela M. Ferreira and Debby Bogaert ()
Additional contact information
Wouter A. A. Steenhuijsen Piters: Wilhelmina Children’s Hospital/University Medical Center Utrecht
Simon P. Jochems: Liverpool School of Tropical Medicine
Elena Mitsi: Liverpool School of Tropical Medicine
Jamie Rylance: Liverpool School of Tropical Medicine
Sherin Pojar: Liverpool School of Tropical Medicine
Elissavet Nikolaou: Liverpool School of Tropical Medicine
Esther L. German: Liverpool School of Tropical Medicine
Mark Holloway: Liverpool School of Tropical Medicine
Beatriz F. Carniel: Liverpool School of Tropical Medicine
Mei Ling J. N. Chu: Wilhelmina Children’s Hospital/University Medical Center Utrecht
Kayleigh Arp: Wilhelmina Children’s Hospital/University Medical Center Utrecht
Elisabeth A. M. Sanders: Wilhelmina Children’s Hospital/University Medical Center Utrecht
Daniela M. Ferreira: Liverpool School of Tropical Medicine
Debby Bogaert: Wilhelmina Children’s Hospital/University Medical Center Utrecht

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract Streptococcus pneumoniae is the main bacterial pathogen involved in pneumonia. Pneumococcal acquisition and colonization density is probably affected by viral co-infections, the local microbiome composition and mucosal immunity. Here, we report the interactions between live-attenuated influenza vaccine (LAIV), successive pneumococcal challenge, and the healthy adult nasal microbiota and mucosal immunity using an experimental human challenge model. Nasal microbiota profiles at baseline are associated with consecutive pneumococcal carriage outcome (non-carrier, low-dense and high-dense pneumococcal carriage), independent of LAIV co-administration. Corynebacterium/Dolosigranulum-dominated profiles are associated with low-density colonization. Lowest rates of natural viral co-infection at baseline and post-LAIV influenza replication are detected in the low-density carriers. Also, we detected the fewest microbiota perturbations and mucosal cytokine responses in the low-density carriers compared to non-carriers or high-density carriers. These results indicate that the complete respiratory ecosystem affects pneumococcal behaviour following challenge, with low-density carriage representing the most stable ecological state.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-10814-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10814-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-10814-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().