Design and fabrication of flexible DNA polymer cocoons to encapsulate live cells

Tao Gao, Tianshu Chen, Chang Feng, Xiang He, Chaoli Mu, Jun-ichi Anzai and Genxi Li ()
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Tao Gao: Shanghai University
Tianshu Chen: Shanghai University
Chang Feng: Nanjing University
Xiang He: Shanghai Jiao Tong University
Chaoli Mu: Nanjing University
Jun-ichi Anzai: Tohoku University
Genxi Li: Shanghai University

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract The capability to encapsulate designated live cells into a biologically and mechanically tunable polymer layer is in high demand. Here, an approach to weave functional DNA polymer cocoons has been proposed as an encapsulation method. By developing in situ DNA-oriented polymerization (isDOP), we demonstrate a localized, programmable, and biocompatible encapsulation approach to graft DNA polymers onto live cells. Further guided by two mutually aided enzymatic reactions, the grafted DNA polymers are assembled into DNA polymer cocoons at the cell surface. Therefore, the coating of bacteria, yeast, and mammalian cells has been achieved. The capabilities of this approach may offer significant opportunities to engineer cell surfaces and enable the precise manipulation of the encapsulated cells, such as encoding, handling, and sorting, for many biomedical applications.

Date: 2019
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DOI: 10.1038/s41467-019-10845-2

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