STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

Pia-Katharina Tegtmeyer, Julia Spanier, Katharina Borst, Jennifer Becker, André Riedl, Christoph Hirche, Luca Ghita, Jennifer Skerra, Kira Baumann, Stefan Lienenklaus, Marius Doering, Zsolt Ruzsics and Ulrich Kalinke ()
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Pia-Katharina Tegtmeyer: Institute for Experimental Infection Research
Julia Spanier: Institute for Experimental Infection Research
Katharina Borst: Institute for Experimental Infection Research
Jennifer Becker: Institute for Experimental Infection Research
André Riedl: University of Freiburg
Christoph Hirche: Institute for Experimental Infection Research
Luca Ghita: Institute for Experimental Infection Research
Jennifer Skerra: Institute for Experimental Infection Research
Kira Baumann: Institute for Experimental Infection Research
Stefan Lienenklaus: Institute for Experimental Infection Research
Marius Doering: Institute for Experimental Infection Research
Zsolt Ruzsics: University of Freiburg
Ulrich Kalinke: Institute for Experimental Infection Research

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Cytomegalovirus is a DNA-encoded β-herpesvirus that induces STING-dependent type 1 interferon responses in macrophages and uses myeloid cells as a vehicle for dissemination. Here we report that STING knockout mice are as resistant to murine cytomegalovirus (MCMV) infection as wild-type controls, whereas mice with a combined Toll-like receptor/RIG-I-like receptor/STING signaling deficiency do not mount type 1 interferon responses and succumb to the infection. Although STING alone is dispensable for survival, early IFN-β induction in Kupffer cells is STING-dependent and controls early hepatic virus propagation. Infection experiments with an inducible reporter MCMV show that STING constrains MCMV replication in myeloid cells and limits viral dissemination via these cells. By contrast, restriction of viral dissemination from hepatocytes to other organs is independent of STING. Thus, during MCMV infection STING is involved in early IFN-β induction in Kupffer cells and the restriction of viral dissemination via myeloid cells, whereas it is dispensable for survival.

Date: 2019
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DOI: 10.1038/s41467-019-10863-0

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