Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

Nadine Bachmann, Chantal Siebenthal, Valentina Vongrad, Teja Turk, Kathrin Neumann, Niko Beerenwinkel, Jasmina Bogojeska, Jaques Fellay, Volker Roth, Yik Lim Kok, Christian W. Thorball, Alessandro Borghesi, Sonali Parbhoo, Mario Wieser, Jürg Böni, Matthieu Perreau, Thomas Klimkait, Sabine Yerly, Manuel Battegay, Andri Rauch, Matthias Hoffmann, Enos Bernasconi, Matthias Cavassini, Roger D. Kouyos, Huldrych F. Günthard () and Karin J. Metzner
Additional contact information
Nadine Bachmann: University Hospital Zurich
Chantal Siebenthal: University Hospital Zurich
Valentina Vongrad: University Hospital Zurich
Teja Turk: University Hospital Zurich
Kathrin Neumann: University Hospital Zurich
Niko Beerenwinkel: Department of Biosystems Science and Engineering, ETH Zurich
Jasmina Bogojeska: IBM Research—Zurich
Jaques Fellay: School of Life Sciences, EPFL
Volker Roth: University of Basel
Yik Lim Kok: University Hospital Zurich
Christian W. Thorball: School of Life Sciences, EPFL
Alessandro Borghesi: School of Life Sciences, EPFL
Sonali Parbhoo: University of Basel
Mario Wieser: University of Basel
Jürg Böni: University of Zurich
Matthieu Perreau: University of Lausanne
Thomas Klimkait: University of Basel
Sabine Yerly: University Hospital Geneva, University of Geneva
Manuel Battegay: University Hospital Basel
Andri Rauch: University Hospital Bern
Matthias Hoffmann: Division of Infectious Diseases, Cantonal Hospital of St. Gallen
Enos Bernasconi: Infectious Diseases Service, Regional Hospital
Matthias Cavassini: Centre Hospitalier Universitaire Vaudois, University of Lausanne
Roger D. Kouyos: University Hospital Zurich
Huldrych F. Günthard: University Hospital Zurich
Karin J. Metzner: University Hospital Zurich

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.

Date: 2019
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DOI: 10.1038/s41467-019-10884-9

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