The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma

Shaodong Hong, Dongbing Liu, Shuzhen Luo, Wenfeng Fang, Jianhua Zhan, Sha Fu, Yaxiong Zhang, Xuan Wu, Huaqiang Zhou, Xi Chen, Gang Chen, Zhonghan Zhang, Qiufan Zheng, Xiaobo Li, Jinghao Chen, Xingmin Liu, Mengyue Lei, Chen Ye, Jian Wang, Huanming Yang, Xun Xu, Shida Zhu, Yunpeng Yang, Yuanyuan Zhao, Ningning Zhou, Hongyun Zhao, Yan Huang, Lanjun Zhang, Kui Wu () and Li Zhang ()
Additional contact information
Shaodong Hong: Sun Yat-sen University Cancer Center
Dongbing Liu: BGI-Shenzhen
Shuzhen Luo: BGI-Shenzhen
Wenfeng Fang: Sun Yat-sen University Cancer Center
Jianhua Zhan: Sun Yat-sen University Cancer Center
Sha Fu: Sun Yat-Sen University
Yaxiong Zhang: Sun Yat-sen University Cancer Center
Xuan Wu: Sun Yat-sen University Cancer Center
Huaqiang Zhou: Sun Yat-sen University Cancer Center
Xi Chen: Sun Yat-sen University Cancer Center
Gang Chen: Sun Yat-sen University Cancer Center
Zhonghan Zhang: Sun Yat-sen University Cancer Center
Qiufan Zheng: Sun Yat-sen University Cancer Center
Xiaobo Li: BGI-Shenzhen
Jinghao Chen: BGI-Shenzhen
Xingmin Liu: BGI-Shenzhen
Mengyue Lei: BGI-Shenzhen
Chen Ye: BGI-Shenzhen
Jian Wang: BGI-Shenzhen
Huanming Yang: BGI-Shenzhen
Xun Xu: BGI-Shenzhen
Shida Zhu: BGI-Shenzhen
Yunpeng Yang: Sun Yat-sen University Cancer Center
Yuanyuan Zhao: Sun Yat-sen University Cancer Center
Ningning Zhou: Sun Yat-sen University Cancer Center
Hongyun Zhao: Sun Yat-sen University Cancer Center
Yan Huang: Sun Yat-sen University Cancer Center
Lanjun Zhang: State Key Laboratory of Oncology in South China
Kui Wu: BGI-Shenzhen
Li Zhang: Sun Yat-sen University Cancer Center

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare and distinct subtype of primary lung cancer characterized by Epstein-Barr virus (EBV) infection. Herein, we reported the mutational landscape of pulmonary LELC using whole-exome sequencing, targeted deep sequencing and single-nucleotide polymorphism arrays. We identify a low degree of somatic mutation but widespread existence of copy number variations. We reveal predominant signature 2 mutations and frequent loss of type I interferon genes that are involved in the host-virus counteraction. Integrated analysis shows enrichment of genetic lesions affecting several critical pathways, including NF-κB, JAK/STAT, and cell cycle. Notably, multi-dimensional comparison unveils that pulmonary LELC resemble NPC but are clearly different from other lung cancers, natural killer/T-cell lymphoma or EBV-related gastric cancer in terms of genetic features. In all, our study illustrates a distinct genomic landscape of pulmonary LELC and provides a road map to facilitate genome-guided personalized treatment.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-10902-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10902-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-10902-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().