Country-wide medical records infer increased allergy risk of gastric acid inhibition

Galateja Jordakieva, Michael Kundi, Eva Untersmayr, Isabella Pali-Schöll, Berthold Reichardt and Erika Jensen-Jarolim ()
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Galateja Jordakieva: Medical University of Vienna
Michael Kundi: Medical University of Vienna
Eva Untersmayr: Medical University of Vienna
Isabella Pali-Schöll: Medical University of Vienna
Berthold Reichardt: Sickness Fund Burgenland
Erika Jensen-Jarolim: Medical University of Vienna

Nature Communications, 2019, vol. 10, issue 1, 1-8

Abstract: Abstract Gastric acid suppression promotes allergy in mechanistic animal experiments and observational human studies, but whether gastric acid inhibitors increase allergy incidence at a population level remains uncharacterized. Here we aim to assess the use of anti-allergic medication following prescription of gastric acid inhibitors. We analyze data from health insurance records covering 97% of Austrian population between 2009 and 2013 on prescriptions of gastric acid inhibitors, anti-allergic drugs, or other commonly prescribed (lipid-modifying and antihypertensive) drugs as controls. Here we show that rate ratios for anti-allergic following gastric acid-inhibiting drug prescriptions are 1.96 (95%CI:1.95–1.97) and 3.07 (95%-CI:2.89–3.27) in an overall and regional Austrian dataset. These findings are more prominent in women and occur for all assessed gastric acid-inhibiting substances. Rate ratios increase from 1.47 (95%CI:1.45–1.49) in subjects 60 year olds. We report an epidemiologic relationship between gastric acid-suppression and development of allergic symptoms.

Date: 2019
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DOI: 10.1038/s41467-019-10914-6

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