The nasal methylome as a biomarker of asthma and airway inflammation in children

Andres Cardenas (), Joanne E. Sordillo, Sheryl L. Rifas-Shiman, Wonil Chung, Liming Liang, Brent A. Coull, Marie-France Hivert, Peggy S. Lai, Erick Forno, Juan C. Celedón, Augusto A. Litonjua, Kasey J. Brennan, Dawn L. DeMeo, Andrea A. Baccarelli, Emily Oken and Diane R. Gold
Additional contact information
Andres Cardenas: University of California, Berkeley
Joanne E. Sordillo: Harvard Medical School and Harvard Pilgrim Health Care Institute
Sheryl L. Rifas-Shiman: Harvard Medical School and Harvard Pilgrim Health Care Institute
Wonil Chung: Harvard T.H. Chan School of Public Health
Liming Liang: Harvard T.H. Chan School of Public Health
Brent A. Coull: Harvard T.H. Chan School of Public Health
Marie-France Hivert: Harvard Medical School and Harvard Pilgrim Health Care Institute
Peggy S. Lai: Pulmonary/Critical Care
Erick Forno: University of Pittsburgh School of Medicine
Juan C. Celedón: University of Pittsburgh School of Medicine
Augusto A. Litonjua: University of Rochester Medical Center
Kasey J. Brennan: Mailman School of Public Health, Columbia University
Dawn L. DeMeo: Harvard Medical School
Andrea A. Baccarelli: Mailman School of Public Health, Columbia University
Emily Oken: Harvard Medical School and Harvard Pilgrim Health Care Institute
Diane R. Gold: Harvard Medical School

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (EWAS) of current asthma, allergen sensitization, allergic rhinitis, fractional exhaled nitric oxide (FeNO) and lung function. We find multiple differentially methylated CpGs (FDR

Date: 2019
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DOI: 10.1038/s41467-019-11058-3

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