Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection

Chen Xu, Yanzhenzi Zhang, Ke Xu, Jing-Jun Nie, Bingran Yu, Sijin Li, Gang Cheng, Yulin Li (), Jie Du () and Fu-Jian Xu ()
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Chen Xu: Beijing University of Chemical Technology
Yanzhenzi Zhang: Beijing Anzhen Hospital Affiliated to Capital Medical University
Ke Xu: Beijing Anzhen Hospital Affiliated to Capital Medical University
Jing-Jun Nie: Beijing University of Chemical Technology
Bingran Yu: Beijing University of Chemical Technology
Sijin Li: The First Hospital of Shanxi Medical University, Molecular Imaging Precision Medical Collaborative Innovation Center, Shanxi Medical University
Gang Cheng: University of Illinois at Chicago
Yulin Li: Beijing Anzhen Hospital Affiliated to Capital Medical University
Jie Du: Beijing Anzhen Hospital Affiliated to Capital Medical University
Fu-Jian Xu: Beijing University of Chemical Technology

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract Thoracic aortic dissection (TAD) is an aggressive vascular disease that requires early diagnosis and effective treatment. However, due to the particular vascular structure and narrowness of lesion location, there are no effective drug delivery systems for the therapy of TAD. Here, we report a multifunctional delivery nanosystem (TP-Gd/miRNA-ColIV) composed of gadolinium-chelated tannic acid (TA), low-toxic cationic PGEA (ethanolamine-aminated poly(glycidyl methacrylate)) and type IV collagen targeted peptide (ColIV) for targeted nucleic acid therapy, early diagnosis and noninvasive monitoring of TAD. Such targeted therapy with miR-145 exhibits impressive performances in stabilizing the vascular structures and preventing the deterioration of TAD. After the treatment with TP-Gd/miR-145-ColIV, nearly no dissection occurs in the thoracic aortic arches of the mice with TAD model. Moreover, TP-Gd/miRNA-ColIV also demonstrates good magnetic resonance imaging (MRI) ability and can be used to noninvasively monitor the development conditions of TAD.

Date: 2019
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DOI: 10.1038/s41467-019-11068-1

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