Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction

Soon-Jung Park, Ri Youn Kim, Bong-Woo Park, Sunghun Lee, Seong Woo Choi, Jae-Hyun Park, Jong Jin Choi, Seok-Won Kim, Jinah Jang, Dong-Woo Cho, Hyung-Min Chung, Sung-Hwan Moon (), Kiwon Ban () and Hun-Jun Park ()
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Soon-Jung Park: Konkuk University School of Medicine
Ri Youn Kim: City University of Hong Kong
Bong-Woo Park: The Catholic University of Korea
Sunghun Lee: City University of Hong Kong
Seong Woo Choi: Konkuk University School of Medicine
Jae-Hyun Park: The Catholic University of Korea
Jong Jin Choi: Konkuk University School of Medicine
Seok-Won Kim: Pohang University of Science and Technology
Jinah Jang: Pohang University of Science and Technology
Dong-Woo Cho: Pohang University of Science and Technology
Hyung-Min Chung: Konkuk University School of Medicine
Sung-Hwan Moon: Konkuk University School of Medicine
Kiwon Ban: City University of Hong Kong
Hun-Jun Park: The Catholic University of Korea

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Since both myocardium and vasculature in the heart are excessively damaged following myocardial infarction (MI), therapeutic strategies for treating MI hearts should concurrently target both so as to achieve true cardiac repair. Here we demonstrate a concomitant method that exploits the advantages of cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) and human mesenchymal stem cell-loaded patch (hMSC-PA) to amplify cardiac repair in a rat MI model. Epicardially implanted hMSC-PA provide a complimentary microenvironment which enhances vascular regeneration through prolonged secretion of paracrine factors, but more importantly it significantly improves the retention and engraftment of intramyocardially injected hiPSC-CMs which ultimately restore the cardiac function. Notably, the majority of injected hiPSC-CMs display adult CMs like morphology suggesting that the secretomic milieu of hMSC-PA constitutes pleiotropic effects in vivo. We provide compelling evidence that this dual approach can be a promising means to enhance cardiac repair on MI hearts.

Date: 2019
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DOI: 10.1038/s41467-019-11091-2

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