Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

Krist Helen Antunes, José Luís Fachi, Rosemeire Paula, Emanuelle Fraga Silva, Laís Passariello Pral, Adara Áurea Santos, Greicy Brisa Malaquias Dias, José Eduardo Vargas, Renato Puga, Fabiana Quoos Mayer, Fábio Maito, Carlos R. Zárate-Bladés, Nadim J. Ajami, Marcella Ramos Sant’Ana, Thamiris Candreva, Hosana Gomes Rodrigues, Marcio Schmiele, Maria Teresa Pedrosa Silva Clerici, José Luiz Proença-Modena, Angélica Thomas Vieira, Charles R. Mackay, Daniel Mansur, Mauricio T. Caballero, Jacqui Marzec, Jianying Li, Xuting Wang, Douglas Bell, Fernando P. Polack, Steven R. Kleeberger, Renato T. Stein, Marco Aurélio Ramirez Vinolo () and Ana Paula Duarte Souza ()
Additional contact information
Krist Helen Antunes: Pontifical Catholic University of Rio Grande do Sul
José Luís Fachi: University of Campinas
Rosemeire Paula: University of Campinas
Emanuelle Fraga Silva: Pontifical Catholic University of Rio Grande do Sul
Laís Passariello Pral: University of Campinas
Adara Áurea Santos: Universidade Federal de Santa Catarina
Greicy Brisa Malaquias Dias: Universidade Federal de Santa Catarina
José Eduardo Vargas: Passo Fundo University
Renato Puga: Hospital Israelita Albert Einstein HIAE
Fabiana Quoos Mayer: Secretariat of Agriculture, Livestock and Irrigation
Fábio Maito: Pontifical Catholic University of Rio Grande do Sul
Carlos R. Zárate-Bladés: Federal University of Santa Catarina, UFSC
Nadim J. Ajami: Baylor College of Medicine
Marcella Ramos Sant’Ana: University of Campinas
Thamiris Candreva: University of Campinas
Hosana Gomes Rodrigues: University of Campinas
Marcio Schmiele: Federal University of Jequitinhonha and Mucuri Valleys (UFVJM)
Maria Teresa Pedrosa Silva Clerici: University of Campinas (UNICAMP) – Cidade Universitária Zeferino Vaz, Monteiro Lobato, 80
José Luiz Proença-Modena: University of Campinas
Angélica Thomas Vieira: Federal University of Minas Gerais
Charles R. Mackay: Monash University
Daniel Mansur: Universidade Federal de Santa Catarina
Mauricio T. Caballero: Fundación INFANT
Jacqui Marzec: National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle
Jianying Li: National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle
Xuting Wang: National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle
Douglas Bell: National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle
Fernando P. Polack: Fundación INFANT
Steven R. Kleeberger: National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle
Renato T. Stein: São Lucas Hospital PUCRS
Marco Aurélio Ramirez Vinolo: University of Campinas
Ana Paula Duarte Souza: Pontifical Catholic University of Rio Grande do Sul

Nature Communications, 2019, vol. 10, issue 1, 1-17

Abstract: Abstract Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants

Date: 2019
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DOI: 10.1038/s41467-019-11152-6

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