Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells

Wen-Long Liu, Mei-Zhen Zou, Tao Liu, Jin-Yue Zeng, Xue Li, Wu-Yang Yu, Chu-Xin Li, Jing-Jie Ye, Wen Song, Jun Feng () and Xian-Zheng Zhang ()
Additional contact information
Wen-Long Liu: Wuhan University
Mei-Zhen Zou: Wuhan University
Tao Liu: Wuhan University
Jin-Yue Zeng: Wuhan University
Xue Li: Wuhan University
Wu-Yang Yu: Wuhan University
Chu-Xin Li: Wuhan University
Jing-Jie Ye: Wuhan University
Wen Song: Wuhan University
Jun Feng: Wuhan University
Xian-Zheng Zhang: Wuhan University

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes of the fused cells (FCs) derived from dendritic cells (DCs) and cancer cells as tumor vaccines. The fusion of immunologically interrelated two types of cells results in strong expression of the whole tumor antigen complexes and the immunological co-stimulatory molecules on cytomembranes (FMs), allowing the nanoparticle-supported FM (NP@FM) to function like antigen presenting cells (APCs) for T cell immunoactivation. Moreover, tumor-antigen bearing NP@FM can be bio-recognized by DCs to induce DC-mediated T cell immunoactivation. The combination of these two immunoactivation pathways offers powerful antitumor immunoresponse. Through mimicking both APCs and cancer cells, this cytomembrane vaccine strategy can develop various vaccines toward multiple tumor types and provide chances for accommodating diverse functions originating from the supporters.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-11157-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11157-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-11157-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().