circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1

Zhuoan Cheng, Chengtao Yu, Shaohua Cui, Hui Wang, Haojie Jin, Cun Wang, Botai Li, Meilin Qin, Chen Yang, Jia He, Qiaozhu Zuo, Siying Wang, Jun Liu, Weidong Ye, Yuanyuan Lv, Fangyu Zhao, Ming Yao, Liyan Jiang () and Wenxin Qin ()
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Zhuoan Cheng: Shanghai Jiao Tong University School of Biomedical Engineering
Chengtao Yu: Shanghai Jiao Tong University School of Biomedical Engineering
Shaohua Cui: Shanghai Jiao Tong University
Hui Wang: Shanghai Jiao Tong University School of Medicine
Haojie Jin: Shanghai Jiao Tong University School of Medicine
Cun Wang: Shanghai Jiao Tong University School of Medicine
Botai Li: Shanghai Jiao Tong University School of Biomedical Engineering
Meilin Qin: Shanghai Jiao Tong University School of Medicine
Chen Yang: Shanghai Medical College of Fudan University
Jia He: Shanghai Jiao Tong University School of Medicine
Qiaozhu Zuo: Shanghai Jiao Tong University School of Medicine
Siying Wang: Shanghai Jiao Tong University School of Medicine
Jun Liu: Shanghai Jiao Tong University
Weidong Ye: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Yuanyuan Lv: Shanghai Jiao Tong University School of Medicine
Fangyu Zhao: Shanghai Jiao Tong University School of Medicine
Ming Yao: Shanghai Jiao Tong University School of Medicine
Liyan Jiang: Shanghai Jiao Tong University
Wenxin Qin: Shanghai Jiao Tong University School of Biomedical Engineering

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown. Herein, we explore the expression profiles of circRNA and mRNA in 5 paired samples of LUSC. By analyzing the co-expression network of differentially expressed circRNAs and dysregulated mRNAs, we identify that a cell cycle-related circRNA, circTP63, is upregulated in LUSC tissues and its upregulation is correlated with larger tumor size and higher TNM stage in LUSC patients. Elevated circTP63 promotes cell proliferation both in vitro and in vivo. Mechanistically, circTP63 shares miRNA response elements with FOXM1. circTP63 competitively binds to miR-873-3p and prevents miR-873-3p to decrease the level of FOXM1, which upregulates CENPA and CENPB, and finally facilitates cell cycle progression.

Date: 2019
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DOI: 10.1038/s41467-019-11162-4

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