Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936

Robert F. Hillary, Daniel L. McCartney, Sarah E. Harris, Anna J. Stevenson, Anne Seeboth, Qian Zhang, David C. Liewald, Kathryn L. Evans, Craig W. Ritchie, Elliot M. Tucker-Drob, Naomi R. Wray, Allan F. McRae, Peter M. Visscher, Ian J. Deary and Riccardo E. Marioni ()
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Robert F. Hillary: University of Edinburgh
Daniel L. McCartney: University of Edinburgh
Sarah E. Harris: University of Edinburgh
Anna J. Stevenson: University of Edinburgh
Anne Seeboth: University of Edinburgh
Qian Zhang: University of Queensland
David C. Liewald: University of Edinburgh
Kathryn L. Evans: University of Edinburgh
Craig W. Ritchie: University of Edinburgh
Elliot M. Tucker-Drob: The University of Texas at Austin
Naomi R. Wray: University of Queensland
Allan F. McRae: University of Queensland
Peter M. Visscher: University of Queensland
Ian J. Deary: University of Edinburgh
Riccardo E. Marioni: University of Edinburgh

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract Although plasma proteins may serve as markers of neurological disease risk, the molecular mechanisms responsible for inter-individual variation in plasma protein levels are poorly understood. Therefore, we conduct genome- and epigenome-wide association studies on the levels of 92 neurological proteins to identify genetic and epigenetic loci associated with their plasma concentrations (n = 750 healthy older adults). We identify 41 independent genome-wide significant (P

Date: 2019
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DOI: 10.1038/s41467-019-11177-x

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