Two types of functionally distinct Ca2+ stores in hippocampal neurons

Hsing-Jung Chen-Engerer, Jana Hartmann, Rosa Maria Karl, Jun Yang, Stefan Feske and Arthur Konnerth ()
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Hsing-Jung Chen-Engerer: Technical University of Munich
Jana Hartmann: Technical University of Munich
Rosa Maria Karl: Technical University of Munich
Jun Yang: New York University
Stefan Feske: New York University
Arthur Konnerth: Technical University of Munich

Nature Communications, 2019, vol. 10, issue 1, 1-8

Abstract: Abstract It is widely assumed that inositol trisphosphate (IP3) and ryanodine (Ry) receptors share the same Ca2+ pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP3- and Ry-receptors are associated with two functionally distinct intracellular Ca2+ stores, respectively. While the IP3-sensitive Ca2+ store refilling requires Orai2 channels, Ry-sensitive Ca2+ store refilling involves voltage-gated Ca2+ channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11207-8

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DOI: 10.1038/s41467-019-11207-8

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