Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles

Tao Tan, Haiyan Hu, Hong Wang, Jie Li, Zhiwan Wang, Jing Wang, Siling Wang, Zhiwen Zhang () and Yaping Li ()
Additional contact information
Tao Tan: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Haiyan Hu: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Hong Wang: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Jie Li: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Zhiwan Wang: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Jing Wang: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Siling Wang: Shenyang Pharmaceutical University
Zhiwen Zhang: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Yaping Li: Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Nature Communications, 2019, vol. 10, issue 1, 1-17

Abstract: Abstract The tumor stromal microenvironments (TSM) including stromal cells and extracellular matrix (ECM) form an abominable barrier hampering nanoparticles accessibility to cancer cells, significantly compromising their antitumor effects. Herein, we report a bioinspired lipoprotein (bLP) that can induce efficient photothermia to remodel TSM and improve second bLP accessibility to cancer cells for antitumor therapy. The multiple stromal cells and ECM components in TSM are remarkably disrupted by bLP-mediated photothermal effects, which cause a 4.27-fold enhancement of second bLP accumulation in tumor, deep penetration in whole tumor mass and 27.0-fold increase of accessibility to cancer cells. Of note, this bLP-mediated TSM-remodeling to enhance cancer cell accessibility (TECA) strategy produces an eminent suppression of tumor growth and results in a 97.4% inhibition of lung metastasis, which is superior to the counterpart liposomes. The bLP-mediated TECA strategy provides deeper insights into enhancing nanoparticle accessibility to cancer cells for antitumor therapy.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-11235-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11235-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-11235-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().