A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

James T. Handa (), Cathy Bowes Rickman, Andrew D. Dick, Michael B. Gorin, Joan W. Miller, Cynthia A. Toth, Marius Ueffing, Marco Zarbin and Lindsay A. Farrer ()
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James T. Handa: Johns Hopkins University
Cathy Bowes Rickman: Duke University Medical Center
Andrew D. Dick: University of Bristol
Michael B. Gorin: UCLA
Joan W. Miller: Harvard Medical School
Cynthia A. Toth: Duke University Medical Center
Marius Ueffing: University of Tübingen
Marco Zarbin: Rutgers University
Lindsay A. Farrer: Boston University Schools of Medicine and Public Health

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or “wet” form of AMD, no therapy is successful for the non-neovascular or “dry” form. Here we discuss the current knowledge on dry AMD pathobiology and propose future research directions that would expedite the development of new treatments. In our view, these should emphasize system biology approaches that integrate omic, pharmacological, and clinical data into mathematical models that can predict disease onset and progression, identify biomarkers, establish disease causing mechanisms, and monitor response to therapy.

Date: 2019
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DOI: 10.1038/s41467-019-11262-1

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