Target specific functions of EPL interneurons in olfactory circuits

Gary Liu, Emmanouil Froudarakis, Jay M. Patel, Mikhail Y. Kochukov, Brandon Pekarek, Patrick J. Hunt, Mayuri Patel, Kevin Ung, Chia-Hsuan Fu, Juyeong Jo, Hyun-Kyoung Lee, Andreas S. Tolias and Benjamin R. Arenkiel ()
Additional contact information
Gary Liu: Baylor College of Medicine
Emmanouil Froudarakis: Baylor College of Medicine
Jay M. Patel: Baylor College of Medicine
Mikhail Y. Kochukov: Baylor College of Medicine
Brandon Pekarek: Baylor College of Medicine
Patrick J. Hunt: Baylor College of Medicine
Mayuri Patel: Baylor College of Medicine
Kevin Ung: Baylor College of Medicine
Chia-Hsuan Fu: Baylor College of Medicine
Juyeong Jo: Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital
Hyun-Kyoung Lee: Baylor College of Medicine
Andreas S. Tolias: Baylor College of Medicine
Benjamin R. Arenkiel: Baylor College of Medicine

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Inhibitory interneurons are integral to sensory processing, yet revealing their cell type-specific roles in sensory circuits remains an ongoing focus. To Investigate the mouse olfactory system, we selectively remove GABAergic transmission from a subset of olfactory bulb interneurons, EPL interneurons (EPL-INs), and assay odor responses from their downstream synaptic partners — tufted cells and mitral cells. Using a combination of in vivo electrophysiological and imaging analyses, we find that inactivating this single node of inhibition leads to differential effects in magnitude, reliability, tuning width, and temporal dynamics between the two principal neurons. Furthermore, tufted and not mitral cell responses to odor mixtures become more linearly predictable without EPL-IN inhibition. Our data suggest that olfactory bulb interneurons, through exerting distinct inhibitory functions onto their different synaptic partners, play a significant role in the processing of odor information.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-11354-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11354-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-11354-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().