Circadian control of lung inflammation in influenza infection

Shaon Sengupta (), Soon Y. Tang, Jill C. Devine, Seán T. Anderson, Soumyashant Nayak, Shirley L. Zhang, Alex Valenzuela, Devin G. Fisher, Gregory R. Grant, Carolina B. López and Garret A. FitzGerald
Additional contact information
Shaon Sengupta: University of Pennsylvania Perelman School of Medicine
Soon Y. Tang: University of Pennsylvania
Jill C. Devine: University of Pennsylvania
Seán T. Anderson: University of Pennsylvania
Soumyashant Nayak: University of Pennsylvania
Shirley L. Zhang: University of Pennsylvania Perelman School of Medicine
Alex Valenzuela: University of Pennsylvania Veterinary School
Devin G. Fisher: University of Pennsylvania Veterinary School
Gregory R. Grant: University of Pennsylvania
Carolina B. López: University of Pennsylvania
Garret A. FitzGerald: University of Pennsylvania

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Influenza is a leading cause of respiratory mortality and morbidity. While inflammation is essential for fighting infection, a balance of anti-viral defense and host tolerance is necessary for recovery. Circadian rhythms have been shown to modulate inflammation. However, the importance of diurnal variability in the timing of influenza infection is not well understood. Here we demonstrate that endogenous rhythms affect survival in influenza infection. Circadian control of influenza infection is mediated by enhanced inflammation as proven by increased cellularity in bronchoalveolar lavage (BAL), pulmonary transcriptomic profile and histology and is not attributable to viral burden. Better survival is associated with a time dependent preponderance of NK and NKT cells and lower proportion of inflammatory monocytes in the lung. Further, using a series of genetic mouse mutants, we elucidate cellular mechanisms underlying circadian gating of influenza infection.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-11400-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11400-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-11400-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().