Maintenance of cell type-specific connectivity and circuit function requires Tao kinase

Federico Marcello Tenedini, Maria Sáez González, Chun Hu, Lisa Hedegaard Pedersen, Mabel Matamala Petruzzi, Bettina Spitzweck, Denan Wang, Melanie Richter, Meike Petersen, Emanuela Szpotowicz, Michaela Schweizer, Stephan J. Sigrist, Froylan Calderon de Anda and Peter Soba ()
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Federico Marcello Tenedini: University Medical Center Hamburg-Eppendorf
Maria Sáez González: University Medical Center Hamburg-Eppendorf
Chun Hu: University Medical Center Hamburg-Eppendorf
Lisa Hedegaard Pedersen: University Medical Center Hamburg-Eppendorf
Mabel Matamala Petruzzi: University Medical Center Hamburg-Eppendorf
Bettina Spitzweck: University Medical Center Hamburg-Eppendorf
Denan Wang: University Medical Center Hamburg-Eppendorf
Melanie Richter: University Medical Center Hamburg-Eppendorf
Meike Petersen: University Medical Center Hamburg-Eppendorf
Emanuela Szpotowicz: University Medical Center Hamburg-Eppendorf
Michaela Schweizer: University Medical Center Hamburg-Eppendorf
Stephan J. Sigrist: Free University Berlin
Froylan Calderon de Anda: University Medical Center Hamburg-Eppendorf
Peter Soba: University Medical Center Hamburg-Eppendorf

Nature Communications, 2019, vol. 10, issue 1, 1-16

Abstract: Abstract Sensory circuits are typically established during early development, yet how circuit specificity and function are maintained during organismal growth has not been elucidated. To gain insight we quantitatively investigated synaptic growth and connectivity in the Drosophila nociceptive network during larval development. We show that connectivity between primary nociceptors and their downstream neurons scales with animal size. We further identified the conserved Ste20-like kinase Tao as a negative regulator of synaptic growth required for maintenance of circuit specificity and connectivity. Loss of Tao kinase resulted in exuberant postsynaptic specializations and aberrant connectivity during larval growth. Using functional imaging and behavioral analysis we show that loss of Tao-induced ectopic synapses with inappropriate partner neurons are functional and alter behavioral responses in a connection-specific manner. Our data show that fine-tuning of synaptic growth by Tao kinase is required for maintaining specificity and behavioral output of the neuronal network during animal growth.

Date: 2019
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DOI: 10.1038/s41467-019-11408-1

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