Genetically diverse Pseudomonas aeruginosa populations display similar transcriptomic profiles in a cystic fibrosis explanted lung

Adrian Kordes, Matthias Preusse, Sven D. Willger, Peter Braubach, Danny Jonigk, Axel Haverich, Gregor Warnecke and Susanne Häussler ()
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Adrian Kordes: Centre for Experimental and Clinical Infection Research
Matthias Preusse: Helmholtz Centre for Infection Research
Sven D. Willger: Centre for Experimental and Clinical Infection Research
Peter Braubach: Hannover Medical School
Danny Jonigk: Hannover Medical School
Axel Haverich: German Center for Lung Research (Deutsches Zentrum für Lungenforschung [DZL])
Gregor Warnecke: German Center for Lung Research (Deutsches Zentrum für Lungenforschung [DZL])
Susanne Häussler: Centre for Experimental and Clinical Infection Research

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Previous studies have demonstrated substantial genetic diversification of Pseudomonas aeruginosa across sub-compartments in cystic fibrosis (CF) lungs. Here, we isolate P. aeruginosa from five different sampling areas in the upper and lower airways of an explanted CF lung, analyze ex vivo transcriptional profiles by RNA-seq, and use colony re-sequencing and deep population sequencing to determine the genetic diversity within and across the various sub-compartments. We find that, despite genetic variation, the ex vivo transcriptional profiles of P. aeruginosa populations inhabiting different regions of the CF lung are similar. Although we cannot estimate the extent to which the transcriptional response recorded here actually reflects the in vivo transcriptomes, our results indicate that there may be a common in vivo transcriptional profile in the CF lung environment.

Date: 2019
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DOI: 10.1038/s41467-019-11414-3

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