GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits

Raha Pazoki, Evangelos Evangelou, David Mosen-Ansorena, Rui Climaco Pinto, Ibrahim Karaman, Paul Blakeley, Dipender Gill, Verena Zuber, Paul Elliott, Ioanna Tzoulaki () and Abbas Dehghan ()
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Raha Pazoki: School of Public Health, St Mary’s campus
Evangelos Evangelou: School of Public Health, St Mary’s campus
David Mosen-Ansorena: School of Public Health, St Mary’s campus
Rui Climaco Pinto: School of Public Health, St Mary’s campus
Ibrahim Karaman: School of Public Health, St Mary’s campus
Paul Blakeley: School of Public Health, St Mary’s campus
Dipender Gill: School of Public Health, St Mary’s campus
Verena Zuber: School of Public Health, St Mary’s campus
Paul Elliott: School of Public Health, St Mary’s campus
Ioanna Tzoulaki: School of Public Health, St Mary’s campus
Abbas Dehghan: School of Public Health, St Mary’s campus

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 50 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary sodium and potassium excretion using data from 446,237 individuals of European descent from the UK Biobank study. We extensively interrogate the results using multiple analyses such as Mendelian randomization, functional assessment, co localization, genetic risk score, and pathway analyses. We identify a shared genetic component between urinary sodium and potassium expression and cardiovascular traits. Ingenuity pathway analysis shows that urinary sodium and potassium excretion loci are over-represented in behavioural response to stimuli. Our study highlights pathways that are shared between urinary sodium and potassium excretion and cardiovascular traits.

Date: 2019
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DOI: 10.1038/s41467-019-11451-y

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