Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

David A. Ruhl, Ewa Bomba-Warczak, Emma T. Watson, Mazdak M. Bradberry, Tabitha A. Peterson, Trina Basu, Alyssa Frelka, Chantell S. Evans, Joseph S. Briguglio, Tamara Basta, Michael H. B. Stowell, Jeffrey N. Savas, Avtar Roopra, Robert A. Pearce, Robert C. Piper and Edwin R. Chapman ()
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David A. Ruhl: University of Wisconsin
Ewa Bomba-Warczak: Northwestern University
Emma T. Watson: University of Wisconsin
Mazdak M. Bradberry: University of Wisconsin
Tabitha A. Peterson: University of Iowa
Trina Basu: University of Wisconsin
Alyssa Frelka: University of Wisconsin
Chantell S. Evans: University of Pennsylvania
Joseph S. Briguglio: University of Wisconsin
Tamara Basta: University of Colorado at Boulder
Michael H. B. Stowell: University of Colorado at Boulder
Jeffrey N. Savas: Northwestern University
Avtar Roopra: University of Wisconsin
Robert A. Pearce: University of Wisconsin
Robert C. Piper: University of Iowa
Edwin R. Chapman: University of Wisconsin

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract The synaptotagmin (syt) proteins have been widely studied for their role in regulating fusion of intracellular vesicles with the plasma membrane. Here we report that syt-17, an unusual isoform of unknown function, plays no role in exocytosis, and instead plays multiple roles in intracellular membrane trafficking. Syt-17 is localized to the Golgi complex in hippocampal neurons, where it coordinates import of vesicles from the endoplasmic reticulum to support neurite outgrowth and facilitate axon regrowth after injury. Further, we discovered a second pool of syt-17 on early endosomes in neurites. Loss of syt-17 disrupts endocytic trafficking, resulting in the accumulation of excess postsynaptic AMPA receptors and defective synaptic plasticity. Two distinct pools of syt-17 thus control two crucial, independent membrane trafficking pathways in neurons. Function of syt-17 appears to be one mechanism by which neurons have specialized their secretory and endosomal systems to support the demands of synaptic communication over sprawling neurite arbors.

Date: 2019
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DOI: 10.1038/s41467-019-11459-4

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