Photo-editable macromolecular information

Niklas Felix König, Abdelaziz Al Ouahabi, Laurence Oswald, Roza Szweda, Laurence Charles and Jean-François Lutz ()
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Niklas Felix König: Université de Strasbourg, CNRS, Institut Charles Sadron UPR22
Abdelaziz Al Ouahabi: Université de Strasbourg, CNRS, Institut Charles Sadron UPR22
Laurence Oswald: Université de Strasbourg, CNRS, Institut Charles Sadron UPR22
Roza Szweda: Université de Strasbourg, CNRS, Institut Charles Sadron UPR22
Laurence Charles: Institute of Radical Chemistry
Jean-François Lutz: Université de Strasbourg, CNRS, Institut Charles Sadron UPR22

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract Light-induced alteration of macromolecular information plays a central role in biology and is known to influence health, aging and Darwinian evolution. Here, we report that light can also trigger sequence variations in abiotic information-containing polymers. Sequence-coded poly(phosphodiester)s were synthesized using four phosphoramidite monomers containing either photo-sensitive or photo-inert substituents. These monomers allow different sequence manipulations. For instance, using two light-cleavable monomers containing o-nitrobenzyl ether and o-nitroveratryl ether motifs, photo-erasable digital polymers were prepared. These polymers can be decoded by tandem mass spectrometry but become unreadable after UVA exposure. The opposite behavior, i.e. photo-revealable sequences, was obtained with polymers made of two isobaric monomers containing light-cleavable o-nitrobenzyl ether and light-inert p-nitrobenzyl ether substituents. Furthermore, when the latter two monomers were used in conjunction with a third monomer bearing a light-inert OH group, site-directed photo-mutations were induced in synthetic polymers. This was used herein to change the meaning of binary sequences.

Date: 2019
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DOI: 10.1038/s41467-019-11566-2

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