Interplay of protein corona and immune cells controls blood residency of liposomes

Francesca Giulimondi, Luca Digiacomo, Daniela Pozzi, Sara Palchetti, Elisabetta Vulpis, Anna Laura Capriotti, Riccardo Zenezini Chiozzi, Aldo Laganà, Heinz Amenitsch, Laura Masuelli, Giovanna Peruzzi, Morteza Mahmoudi (), Isabella Screpanti, Alessandra Zingoni and Giulio Caracciolo ()
Additional contact information
Francesca Giulimondi: Sapienza University of Rome
Luca Digiacomo: Sapienza University of Rome
Daniela Pozzi: Sapienza University of Rome
Sara Palchetti: Sapienza University of Rome
Elisabetta Vulpis: Sapienza University of Rome
Anna Laura Capriotti: Sapienza University of Rome
Riccardo Zenezini Chiozzi: Sapienza University of Rome
Aldo Laganà: Sapienza University of Rome
Heinz Amenitsch: Graz University of Technology
Laura Masuelli: Sapienza University of Rome
Giovanna Peruzzi: Istituto Italiano di Tecnologia, Center for Life Nano Science@Sapienza
Morteza Mahmoudi: Michigan State University
Isabella Screpanti: Sapienza University of Rome
Alessandra Zingoni: Sapienza University of Rome
Giulio Caracciolo: Sapienza University of Rome

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract In vivo liposomes, like other types of nanoparticles, acquire a totally new ‘biological identity’ due to the formation of a biomolecular coating known as the protein corona that depends on and modifies the liposomes’ synthetic identity. The liposome–protein corona is a dynamic interface that regulates the interaction of liposomes with the physiological environment. Here we show that the biological identity of liposomes is clearly linked to their sequestration from peripheral blood mononuclear cells (PBMCs) of healthy donors that ultimately leads to removal from the bloodstream. Pre-coating liposomes with an artificial corona made of human plasma proteins drastically reduces capture by circulating leukocytes in whole blood and may be an effective strategy to enable prolonged circulation in vivo. We conclude with a critical assessment of the key concepts of liposome technology that need to be reviewed for its definitive clinical translation.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/s41467-019-11642-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11642-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-11642-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().