Large-scale parallelization of nanomechanical mass spectrometry with weakly-coupled resonators

Stefano Stassi, Giulia De Laurentis, Debadi Chakraborty, Katarzyna Bejtka, Angelica Chiodoni, John E. Sader () and Carlo Ricciardi ()
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Stefano Stassi: Politecnico di Torino
Giulia De Laurentis: Politecnico di Torino
Debadi Chakraborty: The University of Melbourne
Katarzyna Bejtka: Istituto Italiano di Tecnologia
Angelica Chiodoni: Istituto Italiano di Tecnologia
John E. Sader: The University of Melbourne
Carlo Ricciardi: Politecnico di Torino

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Nanomechanical mass spectrometry is a recent technological breakthrough that enables the real-time analysis of single molecules. In contraposition to its extreme mass sensitivity is a limited capture cross-section that can hinder measurements in a practical setting. Here we show that weak-coupling between devices in resonator arrays can be used in nanomechanical mass spectrometry to parallelize the measurement. This coupling gives rise to asymmetric amplitude peaks in the vibrational response of a single nanomechanical resonator of the array, which coincide with the natural frequencies of all other resonators in the same array. A rigorous theoretical model is derived that explains the physical mechanisms and describes the practical features of this parallelization. We demonstrate the significance of this parallelization through inertial imaging of analytes adsorbed to all resonators of an array, with the possibility of simultaneously detecting resonators placed at distances a hundred times larger than their own physical size.

Date: 2019
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DOI: 10.1038/s41467-019-11647-2

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