Viral priming of cell intrinsic innate antiviral signaling by the unfolded protein response

Tea Carletti, Mohammad Khalid Zakaria, Valentina Faoro, Laura Reale, Yvette Kazungu, Danilo Licastro and Alessandro Marcello ()
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Tea Carletti: International Centre for Genetic Engineering and Biotechnology (ICGEB)
Mohammad Khalid Zakaria: International Centre for Genetic Engineering and Biotechnology (ICGEB)
Valentina Faoro: International Centre for Genetic Engineering and Biotechnology (ICGEB)
Laura Reale: International Centre for Genetic Engineering and Biotechnology (ICGEB)
Yvette Kazungu: International Centre for Genetic Engineering and Biotechnology (ICGEB)
Danilo Licastro: CBM scrl
Alessandro Marcello: International Centre for Genetic Engineering and Biotechnology (ICGEB)

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract The innate response to a pathogen is critical in determining the outcome of the infection. However, the interplay of different cellular responses that are activated following viral infection and their contribution to innate antiviral signalling has not been clearly established. This work shows that flaviviruses, including Dengue, Zika, West Nile and Tick-borne encephalitis viruses, activate the unfolded protein response before transcription of interferon regulatory factor 3 induced genes. Infection in conditions of unfolded protein response priming leads to early activation of innate antiviral responses and cell intrinsic inhibition of viral replication, which is interferon regulatory factor 3 dependent. These results demonstrate that the unfolded protein response is not only a physiological reaction of the cell to viral infection, but also synergizes with pattern recognition sensing to mount a potent antiviral response.

Date: 2019
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DOI: 10.1038/s41467-019-11663-2

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