Glia-neuron interactions underlie state transitions to generalized seizures

Carmen Diaz Verdugo, Sverre Myren-Svelstad, Ecem Aydin, Evelien Van Hoeymissen, Celine Deneubourg, Silke Vanderhaeghe, Julie Vancraeynest, Robbrecht Pelgrims, Mehmet Ilyas Cosacak, Akira Muto, Caghan Kizil, Koichi Kawakami, Nathalie Jurisch-Yaksi () and Emre Yaksi ()
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Carmen Diaz Verdugo: Norwegian University of Science and Technology
Sverre Myren-Svelstad: Norwegian University of Science and Technology
Ecem Aydin: Norwegian University of Science and Technology
Evelien Van Hoeymissen: Norwegian University of Science and Technology
Celine Deneubourg: Norwegian University of Science and Technology
Silke Vanderhaeghe: Norwegian University of Science and Technology
Julie Vancraeynest: Norwegian University of Science and Technology
Robbrecht Pelgrims: Norwegian University of Science and Technology
Mehmet Ilyas Cosacak: Helmholtz Association / Technische Universität Dresden, Center for Molecular and Cellular Bioengineering (CMCB), Center for Regenerative Therapies Dresden (CRTD)
Akira Muto: SOKENDAI (The Graduate University for Advanced Studies), Mishima
Caghan Kizil: Helmholtz Association / Technische Universität Dresden, Center for Molecular and Cellular Bioengineering (CMCB), Center for Regenerative Therapies Dresden (CRTD)
Koichi Kawakami: SOKENDAI (The Graduate University for Advanced Studies), Mishima
Nathalie Jurisch-Yaksi: Norwegian University of Science and Technology
Emre Yaksi: Norwegian University of Science and Technology

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms underlie the state transitions. By studying neural and glial activity in zebrafish models of epileptic seizures, we observe striking differences between these networks. During the preictal period, neurons display a small increase in synchronous activity only locally, while the gap-junction-coupled glial network was highly active and strongly synchronized across large distances. The transition from a preictal state to a generalized seizure leads to an abrupt increase in neural activity and connectivity, which is accompanied by a strong alteration in glia-neuron interactions and a massive increase in extracellular glutamate. Optogenetic activation of glia excites nearby neurons through the action of glutamate and gap junctions, emphasizing a potential role for glia-glia and glia-neuron connections in the generation of epileptic seizures.

Date: 2019
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DOI: 10.1038/s41467-019-11739-z

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