ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice

Huabin Liang, Jinyi Tang, Zhihua Liu, Yuanhua Liu, Yuanyuan Huang, Yongfen Xu, Pei Hao, Zhinan Yin, Jin Zhong, Lilin Ye, Xia Jin () and Haikun Wang ()
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Huabin Liang: Institut Pasteur of Shanghai, Chinese Academy of Sciences
Jinyi Tang: Institut Pasteur of Shanghai, Chinese Academy of Sciences
Zhihua Liu: Institut Pasteur of Shanghai, Chinese Academy of Sciences
Yuanhua Liu: Institut Pasteur of Shanghai, Chinese Academy of Sciences
Yuanyuan Huang: Institut Pasteur of Shanghai, Chinese Academy of Sciences
Yongfen Xu: Institut Pasteur of Shanghai, Chinese Academy of Sciences
Pei Hao: Institut Pasteur of Shanghai, Chinese Academy of Sciences
Zhinan Yin: Jinan University
Jin Zhong: Institut Pasteur of Shanghai, Chinese Academy of Sciences
Lilin Ye: Third Military Medical University
Xia Jin: Institut Pasteur of Shanghai, Chinese Academy of Sciences
Haikun Wang: Institut Pasteur of Shanghai, Chinese Academy of Sciences

Nature Communications, 2019, vol. 10, issue 1, 1-16

Abstract: Abstract Induction of long-lived antibody responses during infection or vaccination is often essential for subsequent protection, but the relative contributions of T follicular helper (Tfh) cells and T helper 1 (Th1) cells for induction of antigen specific antibody responses to viruses are unclear. Here, we establish an acute Zika virus (ZIKV) infection model in immunocompetent mice, and show that ZIKV infection elicits robust Th1-like Tfh cell and protective antibody responses. While these Th1-like Tfh cells share phenotypic and transcriptomic profiles with both Tfh and Th1 cells, they also have unique surface markers and gene expression characteristics, and are dependent on T-bet for their development. Th1-like Tfh cells, but not Th1 cells, are essential for class switching of ZIKV-specific IgG2c antibodies and maintenance of long-term neutralizing antibody responses. Our study suggests that specific modulation of the Th1-like Tfh cell response during infection or vaccination may augment the induction of antiviral antibody response to ZIKV and other viruses.

Date: 2019
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DOI: 10.1038/s41467-019-11754-0

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