Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine

Gwen Lomberk (), Nelson Dusetti, Juan Iovanna and Raul Urrutia ()
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Gwen Lomberk: Medical College of Wisconsin
Nelson Dusetti: INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy
Juan Iovanna: INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy
Raul Urrutia: Medical College of Wisconsin

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Genetic studies have advanced our understanding of pancreatic cancer at a mechanistic and translational level. Genetic concepts and tools are increasingly starting to be applied to clinical practice, in particular for precision medicine efforts. However, epigenomics is rapidly emerging as a promising conceptual and methodological paradigm for advancing the knowledge of this disease. More importantly, recent studies have uncovered potentially actionable pathways, which support the prediction that future trials for pancreatic cancer will involve the vigorous testing of epigenomic therapeutics. Thus, epigenomics promises to generate a significant amount of new knowledge of both biological and medical importance.

Date: 2019
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DOI: 10.1038/s41467-019-11812-7

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