Distinct methylation levels of mature microRNAs in gastrointestinal cancers

Masamitsu Konno, Jun Koseki, Ayumu Asai, Akira Yamagata, Teppei Shimamura, Daisuke Motooka, Daisuke Okuzaki, Koichi Kawamoto, Tsunekazu Mizushima, Hidetoshi Eguchi, Shuji Takiguchi, Taroh Satoh, Koshi Mimori, Takahiro Ochiya, Yuichiro Doki, Ken Ofusa (), Masaki Mori () and Hideshi Ishii ()
Additional contact information
Masamitsu Konno: Osaka University
Jun Koseki: Osaka University
Ayumu Asai: Osaka University
Akira Yamagata: Idea Consultants, Inc., Osaka-city
Teppei Shimamura: Nagoya University Graduate School of Medicine
Daisuke Motooka: Osaka University
Daisuke Okuzaki: Osaka University
Koichi Kawamoto: Osaka University
Tsunekazu Mizushima: Osaka University
Hidetoshi Eguchi: Osaka University
Shuji Takiguchi: Osaka University
Taroh Satoh: Osaka University
Koshi Mimori: Kyushu University Beppu Hospital
Takahiro Ochiya: National Cancer Center Research Institute
Yuichiro Doki: Osaka University
Ken Ofusa: Idea Consultants, Inc., Osaka-city
Masaki Mori: Osaka University
Hideshi Ishii: Osaka University

Nature Communications, 2019, vol. 10, issue 1, 1-7

Abstract: Abstract The biological significance of micro (mi)RNAs has traditionally been evaluated according to their RNA expression levels based on the assumption that miRNAs recognize and regulate their targets in an unvarying fashion. Here we show that a fraction of mature miRNAs including miR-17-5p, -21-5p, and -200c-3p and let-7a-5p harbor methyl marks that potentially alter their stability and target recognition. Importantly, methylation of these miRNAs was significantly increased in cancer tissues as compared to paired normal tissues. Furthermore, miR-17-5p methylation level in serum samples distinguished early pancreatic cancer patients from healthy controls with extremely high sensitivity and specificity. These findings provide a basis for diagnostic strategies for early-stage cancer and add a dimension to our understanding of miRNA biology.

Date: 2019
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DOI: 10.1038/s41467-019-11826-1

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