An ancestral NB-LRR with duplicated 3′UTRs confers stripe rust resistance in wheat and barley

Chaozhong Zhang, Lin Huang, Huifei Zhang, Qunqun Hao, Bo Lyu, Meinan Wang, Lynn Epstein, Miao Liu, Chunlan Kou, Juan Qi, Fengjuan Chen, Mengkai Li, Ge Gao, Fei Ni, Lianquan Zhang, Ming Hao, Jirui Wang, Xianming Chen, Ming-Cheng Luo, Youliang Zheng, Jiajie Wu (), Dengcai Liu () and Daolin Fu ()
Additional contact information
Chaozhong Zhang: Shandong Agricultural University
Lin Huang: Sichuan Agricultural University
Huifei Zhang: University of Idaho
Qunqun Hao: University of Idaho
Bo Lyu: University of Idaho
Meinan Wang: Washington State University
Lynn Epstein: University of California
Miao Liu: Sichuan Agricultural University
Chunlan Kou: Sichuan Agricultural University
Juan Qi: Shandong Agricultural University
Fengjuan Chen: Shandong Agricultural University
Mengkai Li: Shandong Agricultural University
Ge Gao: Shandong Agricultural University
Fei Ni: Shandong Agricultural University
Lianquan Zhang: Sichuan Agricultural University
Ming Hao: Sichuan Agricultural University
Jirui Wang: Sichuan Agricultural University
Xianming Chen: Wheat Health, Genetics, and Quality Research Unit, USDA-ARS
Ming-Cheng Luo: University of California
Youliang Zheng: Sichuan Agricultural University
Jiajie Wu: Shandong Agricultural University
Dengcai Liu: Sichuan Agricultural University
Daolin Fu: University of Idaho

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a global threat to wheat production. Aegilops tauschii, one of the wheat progenitors, carries the YrAS2388 locus for resistance to Pst on chromosome 4DS. We reveal that YrAS2388 encodes a typical nucleotide oligomerization domain-like receptor (NLR). The Pst-resistant allele YrAS2388R has duplicated 3’ untranslated regions and is characterized by alternative splicing in the nucleotide-binding domain. Mutation of the YrAS2388R allele disrupts its resistance to Pst in synthetic hexaploid wheat; transgenic plants with YrAS2388R show resistance to eleven Pst races in common wheat and one race of P. striiformis f. sp. hordei in barley. The YrAS2388R allele occurs only in Ae. tauschii and the Ae. tauschii-derived synthetic wheat; it is absent in 100% (n = 461) of common wheat lines tested. The cloning of YrAS2388R will facilitate breeding for stripe rust resistance in wheat and other Triticeae species.

Date: 2019
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DOI: 10.1038/s41467-019-11872-9

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