Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood

Boris Novakovic, Sharon Lewis, Jane Halliday, Joanne Kennedy, David P. Burgner, Anna Czajko, Bowon Kim, Alexandra Sexton-Oates, Markus Juonala, Karin Hammarberg, David J. Amor, Lex W. Doyle, Sarath Ranganathan, Liam Welsh, Michael Cheung, John McBain, Robert McLachlan and Richard Saffery ()
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Boris Novakovic: Murdoch Children’s Research Institute
Sharon Lewis: Murdoch Children’s Research Institute
Jane Halliday: Murdoch Children’s Research Institute
Joanne Kennedy: Murdoch Children’s Research Institute
David P. Burgner: Murdoch Children’s Research Institute
Anna Czajko: Murdoch Children’s Research Institute
Bowon Kim: Murdoch Children’s Research Institute
Alexandra Sexton-Oates: Murdoch Children’s Research Institute
Markus Juonala: Murdoch Children’s Research Institute
Karin Hammarberg: Monash University
David J. Amor: Murdoch Children’s Research Institute
Lex W. Doyle: Murdoch Children’s Research Institute
Sarath Ranganathan: Murdoch Children’s Research Institute
Liam Welsh: Murdoch Children’s Research Institute
Michael Cheung: Murdoch Children’s Research Institute
John McBain: Royal Women’s Hospital
Robert McLachlan: Hudson Institute of Medical Research
Richard Saffery: Murdoch Children’s Research Institute

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract More than 7 million individuals have been conceived by Assisted Reproductive Technologies (ART) and there is clear evidence that ART is associated with a range of adverse early life outcomes, including rare imprinting disorders. The periconception period and early embryogenesis are associated with widespread epigenetic remodeling, which can be influenced by ART, with effects on the developmental trajectory in utero, and potentially on health throughout life. Here we profile genome-wide DNA methylation in blood collected in the newborn period and in adulthood (age 22–35 years) from a unique longitudinal cohort of ART-conceived individuals, previously shown to have no differences in health outcomes in early adulthood compared with non-ART-conceived individuals. We show evidence for specific ART-associated variation in methylation around birth, most of which occurred independently of embryo culturing. Importantly, ART-associated epigenetic variation at birth largely resolves by adulthood with no direct evidence that it impacts on development and health.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11929-9

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DOI: 10.1038/s41467-019-11929-9

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