Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster

Daniel Wilinski, Jasmine Winzeler, William Duren, Jenna L. Persons, Kristina J. Holme, Johan Mosquera, Morteza Khabiri, Jason M. Kinchen, Peter L. Freddolino, Alla Karnovsky () and Monica Dus ()
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Daniel Wilinski: The University of Michigan, College of Literature, Science, and the Arts
Jasmine Winzeler: The University of Michigan, College of Literature, Science, and the Arts
William Duren: The University of Michigan Medical School
Jenna L. Persons: The University of Michigan, College of Literature, Science, and the Arts
Kristina J. Holme: The University of Michigan Medical School
Johan Mosquera: The University of Michigan Medical School
Morteza Khabiri: The University of Michigan Medical School
Jason M. Kinchen: Metabolon, Inc
Peter L. Freddolino: The University of Michigan Medical School
Alla Karnovsky: The University of Michigan Medical School
Monica Dus: The University of Michigan, College of Literature, Science, and the Arts

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Metabolites are active controllers of cellular physiology, but their role in complex behaviors is less clear. Here we report metabolic changes that occur during the transition between hunger and satiety in Drosophila melanogaster. To analyze these data in the context of fruit fly metabolic networks, we developed Flyscape, an open-access tool. We show that in response to eating, metabolic profiles change in quick, but distinct ways in the heads and bodies. Consumption of a high sugar diet dulls the metabolic and behavioral differences between the fasted and fed state, and reshapes the way nutrients are utilized upon eating. Specifically, we found that high dietary sugar increases TCA cycle activity, alters neurochemicals, and depletes 1-carbon metabolism and brain health metabolites N-acetyl-aspartate and kynurenine. Together, our work identifies the metabolic transitions that occur during hunger and satiation, and provides a platform to study the role of metabolites and diet in complex behavior.

Date: 2019
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DOI: 10.1038/s41467-019-11933-z

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