Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Rubina Tabassum, Joel T. Rämö, Pietari Ripatti, Jukka T. Koskela, Mitja Kurki, Juha Karjalainen, Priit Palta, Shabbeer Hassan, Javier Nunez-Fontarnau, Tuomo T. J. Kiiskinen, Sanni Söderlund, Niina Matikainen, Mathias J. Gerl, Michal A. Surma, Christian Klose, Nathan O. Stitziel, Hannele Laivuori, Aki S. Havulinna, Susan K. Service, Veikko Salomaa, Matti Pirinen, Matti Jauhiainen, Mark J. Daly, Nelson B. Freimer, Aarno Palotie, Marja-Riitta Taskinen, Kai Simons and Samuli Ripatti ()
Additional contact information
Rubina Tabassum: HiLIFE, University of Helsinki
Joel T. Rämö: HiLIFE, University of Helsinki
Pietari Ripatti: HiLIFE, University of Helsinki
Jukka T. Koskela: HiLIFE, University of Helsinki
Mitja Kurki: HiLIFE, University of Helsinki
Juha Karjalainen: HiLIFE, University of Helsinki
Priit Palta: HiLIFE, University of Helsinki
Shabbeer Hassan: HiLIFE, University of Helsinki
Javier Nunez-Fontarnau: HiLIFE, University of Helsinki
Tuomo T. J. Kiiskinen: HiLIFE, University of Helsinki
Sanni Söderlund: Helsinki University Hospital
Niina Matikainen: Helsinki University Hospital
Mathias J. Gerl: Lipotype GmbH
Michal A. Surma: Lipotype GmbH
Christian Klose: Lipotype GmbH
Nathan O. Stitziel: Washington University School of Medicine
Hannele Laivuori: HiLIFE, University of Helsinki
Aki S. Havulinna: HiLIFE, University of Helsinki
Susan K. Service: University of California
Veikko Salomaa: National Institute for Health and Welfare
Matti Pirinen: HiLIFE, University of Helsinki
Matti Jauhiainen: National Institute for Health and Welfare
Mark J. Daly: HiLIFE, University of Helsinki
Nelson B. Freimer: University of California
Aarno Palotie: HiLIFE, University of Helsinki
Marja-Riitta Taskinen: Helsinki University Hospital
Kai Simons: Lipotype GmbH
Samuli Ripatti: HiLIFE, University of Helsinki

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11954-8

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DOI: 10.1038/s41467-019-11954-8

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