Central nicotine induces browning through hypothalamic κ opioid receptor

Patricia Seoane-Collazo, Laura Liñares-Pose, Eva Rial-Pensado, Amparo Romero-Picó, José María Moreno-Navarrete, Noelia Martínez-Sánchez, Pablo Garrido-Gil, Ramón Iglesias-Rey, Donald A. Morgan, Naoki Tomasini, Samuel Andrew Malone, Ana Senra, Cintia Folgueira, Gema Medina-Gomez, Tomás Sobrino, José L. Labandeira-García, Rubén Nogueiras, Ana I. Domingos, José-Manuel Fernández-Real, Kamal Rahmouni, Carlos Diéguez () and Miguel López ()
Additional contact information
Patricia Seoane-Collazo: University of Santiago de Compostela-Instituto de Investigación Sanitaria
Laura Liñares-Pose: University of Santiago de Compostela-Instituto de Investigación Sanitaria
Eva Rial-Pensado: University of Santiago de Compostela-Instituto de Investigación Sanitaria
Amparo Romero-Picó: University of Santiago de Compostela-Instituto de Investigación Sanitaria
José María Moreno-Navarrete: CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)
Noelia Martínez-Sánchez: University of Santiago de Compostela-Instituto de Investigación Sanitaria
Pablo Garrido-Gil: CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
Ramón Iglesias-Rey: Instituto de Investigación Sanitaria
Donald A. Morgan: University of Iowa
Naoki Tomasini: Instituto Gulbenkian de Ciência
Samuel Andrew Malone: University of Oxford
Ana Senra: University of Santiago de Compostela-Instituto de Investigación Sanitaria
Cintia Folgueira: University of Santiago de Compostela-Instituto de Investigación Sanitaria
Gema Medina-Gomez: Universidad Rey Juan Carlos
Tomás Sobrino: Instituto de Investigación Sanitaria
José L. Labandeira-García: CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
Rubén Nogueiras: University of Santiago de Compostela-Instituto de Investigación Sanitaria
Ana I. Domingos: University of Oxford
José-Manuel Fernández-Real: CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)
Kamal Rahmouni: University of Iowa
Carlos Diéguez: University of Santiago de Compostela-Instituto de Investigación Sanitaria
Miguel López: University of Santiago de Compostela-Instituto de Investigación Sanitaria

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Increased body weight is a major factor that interferes with smoking cessation. Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both feeding and energy expenditure at the central level. Among the central actions of nicotine on body weight, much attention has been focused on its effect on brown adipose tissue (BAT) thermogenesis, though its effect on browning of white adipose tissue (WAT) is unclear. Here, we show that nicotine induces the browning of WAT through a central mechanism and that this effect is dependent on the κ opioid receptor (KOR), specifically in the lateral hypothalamic area (LHA). Consistent with these findings, smokers show higher levels of uncoupling protein 1 (UCP1) expression in WAT, which correlates with smoking status. These data demonstrate that central nicotine-induced modulation of WAT browning may be a target against human obesity.

Date: 2019
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DOI: 10.1038/s41467-019-12004-z

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