Hippocampal-neocortical interactions sharpen over time for predictive actions

Nicholas C. Hindy (), Emily W. Avery and Nicholas B. Turk-Browne
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Nicholas C. Hindy: University of Louisville
Emily W. Avery: Psychology, Yale University
Nicholas B. Turk-Browne: Psychology, Yale University

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract When an action is familiar, we are able to anticipate how it will change the state of the world. These expectations can result from retrieval of action-outcome associations in the hippocampus and the reinstatement of anticipated outcomes in visual cortex. How does this role for the hippocampus in action-based prediction change over time? We use high-resolution fMRI and a dual-training behavioral paradigm to examine how the hippocampus interacts with visual cortex during predictive and nonpredictive actions learned either three days earlier or immediately before the scan. Just-learned associations led to comparable background connectivity between the hippocampus and V1/V2, regardless of whether actions predicted outcomes. However, three-day-old associations led to stronger background connectivity and greater differentiation between neural patterns for predictive vs. nonpredictive actions. Hippocampal prediction may initially reflect indiscriminate binding of co-occurring events, with action information pruning weaker associations and leading to more selective and accurate predictions over time.

Date: 2019
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DOI: 10.1038/s41467-019-12016-9

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