The transferability of lipid loci across African, Asian and European cohorts

Karoline Kuchenbaecker (), Nikita Telkar, Theresa Reiker, Robin G. Walters, Kuang Lin, Anders Eriksson, Deepti Gurdasani, Arthur Gilly, Lorraine Southam, Emmanouil Tsafantakis, Maria Karaleftheri, Janet Seeley, Anatoli Kamali, Gershim Asiki, Iona Y. Millwood, Michael Holmes, Huaidong Du, Yu Guo, Meena Kumari, George Dedoussis, Liming Li, Zhengming Chen, Manjinder S. Sandhu and Eleftheria Zeggini
Additional contact information
Karoline Kuchenbaecker: University College of London
Nikita Telkar: University College London
Theresa Reiker: Wellcome Sanger Institute
Robin G. Walters: University of Oxford
Kuang Lin: University of Oxford
Anders Eriksson: King’s College London
Deepti Gurdasani: Wellcome Sanger Institute
Arthur Gilly: Wellcome Sanger Institute
Lorraine Southam: Wellcome Sanger Institute
Emmanouil Tsafantakis: Anogia Medical Centre
Maria Karaleftheri: Echinos Medical Centre, Echinos
Janet Seeley: London School of Hygiene & Tropical Medicine
Anatoli Kamali: Uganda Research Unit
Gershim Asiki: Uganda Research Unit
Iona Y. Millwood: University of Oxford
Michael Holmes: University of Oxford
Huaidong Du: University of Oxford
Yu Guo: Chinese Academy of Medical Sciences
Meena Kumari: University of Essex
George Dedoussis: Harokopio University of Athens
Liming Li: School of Public Health, Peking University
Zhengming Chen: University of Oxford
Manjinder S. Sandhu: University of Cambridge
Eleftheria Zeggini: Wellcome Sanger Institute

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in samples from the UK, Uganda and Greece (r = 0.23–0.28, p

Date: 2019
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DOI: 10.1038/s41467-019-12026-7

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