Bridging of Neisseria gonorrhoeae lineages across sexual networks in the HIV pre-exposure prophylaxis era

Deborah A. Williamson (), Eric P. F. Chow, Claire L. Gorrie, Torsten Seemann, Danielle J. Ingle, Nasra Higgins, Marion Easton, George Taiaroa, Yonatan H. Grad, Jason C. Kwong, Christopher K. Fairley, Marcus Y. Chen and Benjamin P. Howden
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Deborah A. Williamson: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Eric P. F. Chow: Melbourne Sexual Health Centre, Alfred Health
Claire L. Gorrie: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Torsten Seemann: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Danielle J. Ingle: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Nasra Higgins: Victorian Department of Health and Human Services
Marion Easton: Victorian Department of Health and Human Services
George Taiaroa: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Yonatan H. Grad: Harvard T. H. Chan School of Public Health
Jason C. Kwong: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
Christopher K. Fairley: Melbourne Sexual Health Centre, Alfred Health
Marcus Y. Chen: Melbourne Sexual Health Centre, Alfred Health
Benjamin P. Howden: The University of Melbourne at The Peter Doherty Institute for Infection and Immunity

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Whole genome sequencing (WGS) has been used to investigate transmission of Neisseria gonorrhoeae, but to date, most studies have not combined genomic data with detailed information on sexual behaviour to define the extent of transmission across population risk groups (bridging). Here, through combined epidemiological and genomic analysis of 2,186N. gonorrhoeae isolates from Australia, we show widespread transmission of N. gonorrhoeae within and between population groups. We describe distinct transmission clusters associated with men who have sex with men (MSM) and heterosexuals, and men who have sex with men and women (MSMW) are identified as a possible bridging population between these groups. Further, the study identifies transmission of N. gonorrhoeae between HIV-positive and HIV-negative individuals receiving pre-exposure prophylaxis (PrEP). Our data highlight several groups that can be targeted for interventions aimed at improving gonorrhoea control, including returning travellers, sex workers, and PrEP users.

Date: 2019
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DOI: 10.1038/s41467-019-12053-4

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