Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions

Dorothee Bornhorst, Peng Xia, Hiroyuki Nakajima, Chaitanya Dingare, Wiebke Herzog, Virginie Lecaudey, Naoki Mochizuki, Carl-Philipp Heisenberg, Deborah Yelon and Salim Abdelilah-Seyfried ()
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Dorothee Bornhorst: Potsdam University
Peng Xia: Institute of Science and Technology Austria
Hiroyuki Nakajima: National Cerebral and Cardiovascular Center Research Institute
Chaitanya Dingare: Goethe Universität Frankfurt am Main
Wiebke Herzog: Max Planck Institute for Molecular Biomedicine
Virginie Lecaudey: Goethe Universität Frankfurt am Main
Naoki Mochizuki: National Cerebral and Cardiovascular Center Research Institute
Carl-Philipp Heisenberg: Institute of Science and Technology Austria
Deborah Yelon: University of California, San Diego
Salim Abdelilah-Seyfried: Potsdam University

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Intra-organ communication guides morphogenetic processes that are essential for an organ to carry out complex physiological functions. In the heart, the growth of the myocardium is tightly coupled to that of the endocardium, a specialized endothelial tissue that lines its interior. Several molecular pathways have been implicated in the communication between these tissues including secreted factors, components of the extracellular matrix, or proteins involved in cell-cell communication. Yet, it is unknown how the growth of the endocardium is coordinated with that of the myocardium. Here, we show that an increased expansion of the myocardial atrial chamber volume generates higher junctional forces within endocardial cells. This leads to biomechanical signaling involving VE-cadherin, triggering nuclear localization of the Hippo pathway transcriptional regulator Yap1 and endocardial proliferation. Our work suggests that the growth of the endocardium results from myocardial chamber volume expansion and ends when the tension on the tissue is relaxed.

Date: 2019
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DOI: 10.1038/s41467-019-12068-x

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