A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates

Yuelan Yin (), Hao Yao, Swapnil Doijad, Suwei Kong, Yang Shen, Xuexue Cai, Weijun Tan, Yuting Wang, Youwei Feng, Zhiting Ling, Guoliang Wang, Yachen Hu, Kai Lian, Xinyu Sun, Yuliang Liu, Chuanbin Wang, Kuhua Jiao, Guoping Liu, Ruilong Song, Xiang Chen, Zhiming Pan, Martin J. Loessner, Trinad Chakraborty () and Xin’an Jiao ()
Additional contact information
Yuelan Yin: Yangzhou University
Hao Yao: Yangzhou University
Swapnil Doijad: Justus-Liebig University
Suwei Kong: Yangzhou University
Yang Shen: ETH Zurich
Xuexue Cai: Yangzhou University
Weijun Tan: Yangzhou University
Yuting Wang: Yangzhou University
Youwei Feng: Yangzhou University
Zhiting Ling: Yangzhou University
Guoliang Wang: Yangzhou University
Yachen Hu: Yangzhou University
Kai Lian: Yangzhou University
Xinyu Sun: Yangzhou University
Yuliang Liu: China Animal Disease Control Center
Chuanbin Wang: China Animal Disease Control Center
Kuhua Jiao: Yangzhou University
Guoping Liu: Xuyi Center for Animal Disease Control and Prevention
Ruilong Song: Yangzhou University
Xiang Chen: Yangzhou University
Zhiming Pan: Yangzhou University
Martin J. Loessner: ETH Zurich
Trinad Chakraborty: Yangzhou University
Xin’an Jiao: Yangzhou University

Nature Communications, 2019, vol. 10, issue 1, 1-16

Abstract: Abstract The foodborne pathogen Listeria monocytogenes (Lm) is a highly heterogeneous species and currently comprises of 4 evolutionarily distinct lineages. Here, we characterize isolates from severe ovine listeriosis outbreaks that represent a hybrid sub-lineage of the major lineage II (HSL-II) and serotype 4h. HSL-II isolates are highly virulent and exhibit higher organ colonization capacities than well-characterized hypervirulent strains of Lm in an orogastric mouse infection model. The isolates harbour both the Lm Pathogenicity Island (LIPI)-1 and a truncated LIPI-2 locus, encoding sphingomyelinase (SmcL), a virulence factor required for invasion and bacterial translocation from the gut, and other non-contiguous chromosomal segments from another pathogenic species, L. ivanovii. HSL-II isolates exhibit a unique wall teichoic acid (WTA) structure essential for resistance to antimicrobial peptides, bacterial invasion and virulence. The discovery of isolates harbouring pan-species virulence genes of the genus Listeria warrants global efforts to identify further hypervirulent lineages of Lm.

Date: 2019
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DOI: 10.1038/s41467-019-12072-1

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