Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast

So Dam Ha, Seokjin Ham, Min Young Kim, Ji Hyun Kim, Insoon Jang, Bo Bae Lee, Min Kyung Lee, Jin-Taek Hwang, Tae-Young Roh () and TaeSoo Kim ()
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So Dam Ha: Ewha Womans University
Seokjin Ham: Pohang University of Science and Technology (POSTECH)
Min Young Kim: Ewha Womans University
Ji Hyun Kim: Ewha Womans University
Insoon Jang: Pohang University of Science and Technology (POSTECH)
Bo Bae Lee: Ewha Womans University
Min Kyung Lee: Ewha Womans University
Jin-Taek Hwang: Korea Food Research Institute
Tae-Young Roh: Pohang University of Science and Technology (POSTECH)
TaeSoo Kim: Ewha Womans University

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract In yeast, Hda1 histone deacetylase complex (Hda1C) preferentially deacetylates histones H3 and H2B, and functionally interacts with Tup1 to repress transcription. However, previous studies identified global increases in histone H4 acetylation in cells lacking Hda1, a component of Hda1C. Here, we find that Hda1C binds to hyperactive genes, likely via the interaction between the Arb2 domain of Hda1 and RNA polymerase II. Additionally, we report that Hda1C specifically deacetylates H4, but not H3, at hyperactive genes to partially inhibit elongation. This role is contrast to that of the Set2–Rpd3S pathway deacetylating histones at infrequently transcribed genes. We also find that Hda1C deacetylates H3 at inactive genes to delay the kinetics of gene induction. Therefore, in addition to fine-tuning of transcriptional response via H3-specific deacetylation, Hda1C may modulate elongation by specifically deacetylating H4 at highly transcribed regions.

Date: 2019
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DOI: 10.1038/s41467-019-12077-w

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