A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome

Suhn Kyong Rhie (), Andrew A. Perez, Fides D. Lay, Shannon Schreiner, Jiani Shi, Jenevieve Polin and Peggy J. Farnham ()
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Suhn Kyong Rhie: University of Southern California
Andrew A. Perez: University of Southern California
Fides D. Lay: University of Southern California
Shannon Schreiner: University of Southern California
Jiani Shi: University of Southern California
Jenevieve Polin: University of Southern California
Peggy J. Farnham: University of Southern California

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract To better understand the impact of chromatin structure on regulation of the prostate cancer transcriptome, we develop high-resolution chromatin interaction maps in normal and prostate cancer cells using in situ Hi-C. By combining the in situ Hi-C data with active and repressive histone marks, CTCF binding sites, nucleosome-depleted regions, and transcriptome profiling, we identify topologically associating domains (TADs) that change in size and epigenetic states between normal and prostate cancer cells. Moreover, we identify normal and prostate cancer-specific enhancer-promoter loops and involved transcription factors. For example, we show that FOXA1 is enriched in prostate cancer-specific enhancer-promoter loop anchors. We also find that the chromatin structure surrounding the androgen receptor (AR) locus is altered in the prostate cancer cells with many cancer-specific enhancer-promoter loops. This creation of 3D epigenomic maps enables a better understanding of prostate cancer biology and mechanisms of gene regulation.

Date: 2019
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DOI: 10.1038/s41467-019-12079-8

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